Two sample MR report
HLA-DQA2_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 102 | -0.0124802 | 0.0136455 | 0.3626007 |
| Weighted median | 102 | 0.0099400 | 0.0039899 | 0.0127281 |
| Inverse variance weighted | 102 | 0.0087053 | 0.0030498 | 0.0043121 |
| Simple mode | 102 | 0.0110518 | 0.0098581 | 0.2649072 |
| Weighted mode | 102 | 0.0113810 | 0.0087322 | 0.1954237 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 33.72455 | 100 | 1 |
| Inverse variance weighted | 36.26173 | 101 | 1 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0259926 | 0.0163183 | 0.1143492 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0030542 | 0 | TRUE | 1e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
